Abstract:
:In this study we identify the molecules involved in the MAPK signal transduction pathway (Ras, Raf-1, Mek, Mek-P and MAPK) in highly purified endosomal fractions isolated from rat liver. Biochemical analysis shows that only the early-sorting endocytic compartment contains activated Raf-1 and Mek. Finally, the exogenous administration of EGF led to redistribution of Raf-1 from the caveolin-enriched plasma membrane into the endosomes.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Pol A,Calvo M,Enrich Cdoi
10.1016/s0014-5793(98)01517-8subject
Has Abstractpub_date
1998-12-11 00:00:00pages
34-8issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(98)01517-8journal_volume
441pub_type
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