Abstract:
:Obesity is linked to functional brown adipose tissue (BAT) atrophy, partially due to adipocyte apoptosis. The brown adipocytes of obese rats have lower Bcl-2/Bax mRNA and protein ratios than those of their lean littermates. Exposure to a low temperature for three days markedly increased the Bcl-2/Bax ratio, by increasing the noradrenergic output to BAT, which has previously been shown to reduce apoptotic cell death. This effect could be mimicked in vitro by the addition of noradrenaline (NA) to brown adipocytes differentiated in culture. Micromolar NA concentrations increased the Bcl-2/Bax mRNA and protein ratios, and protected against serum deprivation-induced apoptosis. We conclude that NA acts by modulating bcl-2 and bax gene expression.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Briscini L,Tonello C,Dioni L,Carruba MO,Nisoli Edoi
10.1016/s0014-5793(98)00730-3subject
Has Abstractpub_date
1998-07-10 00:00:00pages
80-4issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(98)00730-3journal_volume
431pub_type
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