Abstract:
:Rho proteins and phosphatidylinositide 3-kinases (PI 3-kinases) have been widely implicated in regulating cell motility both in cultured cells and in animal models. Monocytes are recruited from the bloodstream in response to inflammatory signals, and migrate across the endothelial barrier into the tissues, where they differentiate into macrophages and phagocytose bacteria and cells. Studies of monocytes and macrophages have revealed that different Rho family members and PI 3-kinases are not functionally redundant but play unique and distinct roles in motile responses.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Ridley AJdoi
10.1016/s0014-5793(01)02481-4keywords:
subject
Has Abstractpub_date
2001-06-08 00:00:00pages
168-71issue
2-3eissn
0014-5793issn
1873-3468pii
S0014-5793(01)02481-4journal_volume
498pub_type
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