Abstract:
:The presence of synaptic proteins involved in excitation/secretion coupling was examined in ten small cell lung cancer lines. N-Type calcium channels (omega-conotoxin receptors), synaptotagmin (p65) and syntaxin (HPC-1) were detected in eight. Co-immunoprecipitation experiments indicated that syntaxin can form a complex with synaptotagmin and calcium channels. The expression of synaptotagmin in small cell lung cancer may elicit an autoimmune response that reduces transmitter release at the nerve terminal.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
David P,el Far O,Martin-Mouto N,Poupon MF,Takahashi M,Seagar MJdoi
10.1016/0014-5793(93)81777-wsubject
Has Abstractpub_date
1993-07-12 00:00:00pages
135-9issue
1-3eissn
0014-5793issn
1873-3468pii
0014-5793(93)81777-Wjournal_volume
326pub_type
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