Abstract:
:VacA is a major virulence factor of the widespread stomach-dwelling bacterium Helicobacter pylori. It causes cell vacuolation and tissue damage by forming anion-selective, urea-permeable channels in plasma and endosomal membranes. We report that several flavone derivatives and other polyphenols present in vegetables and plants inhibit ion and urea conduction and cell vacuolation by VacA. Red wine and green tea, which contain many of the compounds in question, also potently inhibit the toxin. These observations suggest that polyphenols or polyphenol derivatives may be useful in the prevention or cure of H. pylori-associated gastric diseases.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Tombola F,Campello S,De Luca L,Ruggiero P,Del Giudice G,Papini E,Zoratti Mdoi
10.1016/s0014-5793(03)00443-5keywords:
subject
Has Abstractpub_date
2003-05-22 00:00:00pages
184-9issue
1-3eissn
0014-5793issn
1873-3468pii
S0014579303004435journal_volume
543pub_type
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