Abstract:
:Rat liver plasma membrane removed sialic acid from mixed bovine brain gangliosides more efficiently than from sialyllactose and orosomucoid with an optimal pH of 4.5. When individual gangliosides, each labeled with [14C]sialic acid or [3H]sphingosine, were tested, not only GD1a and GM3 but also GM2 and GM1, both of which had been considered to resist mammalian sialidases, were desialylated. The products of GM2 and GM1 hydrolysis were identified as asialo-GM2 and asialo-GM1, respectively, by thin-layer chromatography.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Miyagi T,Tsuiki Sdoi
10.1016/0014-5793(86)80985-1subject
Has Abstractpub_date
1986-10-06 00:00:00pages
223-8issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(86)80985-1journal_volume
206pub_type
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