Abstract:
:Particulate drug carriers, including liposomes, are rapidly removed from blood by cells of the reticuloendothelial system (RES) with resulting adverse effects on this important host defense system. In order to overcome this and other major disadvantages of liposomes, we have altered liposome composition in an effort to achieve prolonged circulation half-lives. Gangliosides and sphingomyelin act synergistically to dramatically diminish the rate and extent of uptake of liposomes by macrophages in vivo. The significantly extended circulation times achieved by these modified large unilamellar liposomes overcome an important barrier to the targeting of particulate drug carriers to specific tissues in vivo.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Allen TM,Chonn Adoi
10.1016/0014-5793(87)80506-9subject
Has Abstractpub_date
1987-10-19 00:00:00pages
42-6issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(87)80506-9journal_volume
223pub_type
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