Abstract:
:Nitrogen dioxide (NO2.) is often present in inhaled air and may be generated in vivo from nitric oxide. Exposure of human blood plasma to NO2. caused rapid losses of ascorbic acid, uric acid and protein thiol groups, as well as lipid peroxidation and depletions of alpha-tocopherol, bilirubin and ubiquinol-10. No increase in protein carbonyls was detected. Supplementation of plasma with ascorbate decreased the rates of lipid peroxidation, alpha-tocopherol depletion and loss of uric acid. Uric acid supplementation decreased rates of lipid peroxidation but not the loss of alpha-tocopherol. We conclude that ascorbic acid, protein -SH groups, uric acid and alpha-tocopherol may be important agents protecting against NO2. in vivo. If these antioxidants are depleted, peroxidation of lipids occurs and might contribute to the toxicity of NO2..
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Halliwell B,Hu ML,Louie S,Duvall TR,Tarkington BK,Motchnik P,Cross CEdoi
10.1016/0014-5793(92)81185-okeywords:
subject
Has Abstractpub_date
1992-11-16 00:00:00pages
62-6issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(92)81185-Ojournal_volume
313pub_type
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