Single-chain precursor of renal gamma-glutamyl transpeptidase.

Abstract:

:The two subunits of gamma-glutamyl transpeptidase (EC 2.3.2.2) are derived from a single-chain glycosylated precursor. A small fraction of the propeptide survives proteolytic processing in the rat kidney and has been purified by an immunoaffinity technique. The propeptide contains determinants for both the subunits and its amino acid composition resembles that of the dimeric enzyme. However, the propeptide exhibits less than 2% of the transpeptidase activity shown by the dimeric enzyme.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Tate SS

doi

10.1016/0014-5793(86)80046-1

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

33-8

issue

1

eissn

0014-5793

issn

1873-3468

pii

0014-5793(86)80046-1

journal_volume

194

pub_type

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