Abstract:
:In Drosophila, the tumor suppressor Scribble is localized at the septate junctions of epithelial cells. Its mammalian homologue, hScrib, is a basolateral protein likely associated to proteins of the cell-cell junctions. We report the direct interaction between hScrib and ZO-2, a junction-associated protein. This interaction relies on two PDZ domains of hScrib and on the C-terminal motif of ZO-2. Both proteins localise at cell-cell junctions of epithelial cells. A point mutation in the LRR of hScrib delocalises the protein from the plasma membrane and abrogates the interaction with ZO-2 but not with betaPIX. Tyrosine phosphorylation of hScrib does not impair the interaction with ZO-2. We show a direct link between two junctional proteins that are down-regulated during cancer progression.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Métais JY,Navarro C,Santoni MJ,Audebert S,Borg JPdoi
10.1016/j.febslet.2005.05.062keywords:
subject
Has Abstractpub_date
2005-07-04 00:00:00pages
3725-30issue
17eissn
0014-5793issn
1873-3468pii
S0014-5793(05)00687-3journal_volume
579pub_type
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