Chemical chronobiology: Toward drugs manipulating time.

Abstract:

:Circadian clocks are endogenous timing systems orchestrating the daily regulation of a huge variety of physiological, metabolic and behavioral processes. These clocks are important for health - in mammals, their disruption leads to a diverse number of pathologies. While genetic and biochemical approaches largely uncovered the molecular bases of circadian rhythm generation, chemical biology strategies targeting the circadian oscillator by small chemical compounds are increasingly developed. Here, we review the recent progress in the identification of small molecules modulating circadian rhythms. We focus on high-throughput screening approaches using circadian bioluminescence reporter cell lines as well as describe alternative mechanistic screens. Furthermore, we discuss the potential for chemical optimization of small molecule ligands with regard to the recent progress in structural chronobiology.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Wallach T,Kramer A

doi

10.1016/j.febslet.2015.04.059

subject

Has Abstract

pub_date

2015-06-22 00:00:00

pages

1530-8

issue

14

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(15)00351-8

journal_volume

589

pub_type

杂志文章,评审
  • Protein kinase C during differentiation of human promyelocytic leukemia cell line, HL-60.

    abstract::Protein kinase C (PKC) from human promyelocytic leukemia HL-60 cells can be resolved into three fractions (peak, a, b and c) by hydroxyapatite column chromatography. Peak a and c enzymes are indistinguishable from the brain type II PKC having beta (beta I and beta II)-sequence and type III having alpha-sequence, respe...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(90)80698-i

    authors: Hashimoto K,Kishimoto A,Aihara H,Yasuda I,Mikawa K,Nishizuka Y

    更新日期:1990-04-09 00:00:00

  • Autophosphorylation of the two C-terminal tyrosine residues Tyr1316 and Tyr1322 modulates the activity of the insulin receptor kinase in vitro.

    abstract::Previously, several studies have demonstrated that autophosphorylation of the C-terminal tyrosine residues (Tyr1316 and Tyr1322) affects the signaling properties of the insulin receptor in vivo. To assess the biochemical consequences of the C-terminal phosphorylation in vitro, we have constructed, purified and charact...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/s0014-5793(00)01879-2

    authors: Tennagels N,Bergschneider E,Al-Hasani H,Klein HW

    更新日期:2000-08-11 00:00:00

  • Glyoxalase I of the malarial parasite Plasmodium falciparum: evidence for subunit fusion.

    abstract::Recombinant Plasmodium falciparum glyoxalase I (PfGlx I) was characterized as monomeric Zn(2+)-containing enzyme of 44 kDa. The K(M) value of the methylglyoxal-glutathione adduct is 77+/-15 microM, the k(cat) value being 4000 min(-1) at 25 degrees C and pH 7.0. PfGlx I consists of two halves, each of which is homologo...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/s0014-5793(03)01146-3

    authors: Iozef R,Rahlfs S,Chang T,Schirmer H,Becker K

    更新日期:2003-11-20 00:00:00

  • The N-terminal region of the alpha-subunit of the TRAP complex has a conserved cluster of negative charges.

    abstract::The alpha-subunit of the TRAP complex (TRAP alpha) is a single-spanning membrane protein of the endoplasmic reticulum (ER) which is found in proximity of nascent polypeptide chains translocating across the membrane. Here, we demonstrate the widespread occurrence of TRAP alpha in eukaryotes as indicated by its existenc...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(94)00693-8

    authors: Hartmann E,Prehn S

    更新日期:1994-08-08 00:00:00

  • Interleukin-2-dependent regulation of Na/K pump in human lymphocytes.

    abstract::The present study provides the first evidence that the abundance of catalytic alpha1-subunit of Na,K-ATPase increases in the course of T cell blast transformation. Immunodepressant cyclosporin A at anti-proliferative doses diminished the induction of alpha1 protein in activated lymphocytes. Furthermore, in competent T...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/j.febslet.2005.03.096

    authors: Marakhova I,Karitskaya I,Aksenov N,Zenin V,Vinogradova T

    更新日期:2005-05-23 00:00:00

  • Do monoclonal antibodies Tü15 and Tü67 detect heterogeneity of human transferrin receptor molecules?

    abstract::The possible molecular heterogeneity of human transferrin receptors was analyzed using two murine monoclonal antibodies, Tü15 and Tü67. Both reagents precipitated from lysates of 125I-labeled HL-60 cells a major component of 88 kDa which could be identified as the transferrin receptor by comparison with the proteins d...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(84)80751-6

    authors: Uchańska-Ziegler B,Wernet P,Liangru S,Ziegler A

    更新日期:1984-10-01 00:00:00

  • A mammalian insulysin homolog is regulated by enzyme IIA(Glc) of the glucose transport system in Vibrio vulnificus.

    abstract::Vibrio vulnificus is an opportunistic human pathogen that causes severe infections in susceptible individuals. While the components of the Escherichia coli phosphoenolpyruvate: sugar phosphotransferase system (PTS) have been shown to regulate numerous targets, little such information is available for the V. vulnificus...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/j.febslet.2010.10.035

    authors: Kim YJ,Ryu Y,Koo BM,Lee NY,Chun SJ,Park SJ,Lee KH,Seok YJ

    更新日期:2010-11-19 00:00:00

  • The chloride channel blocker 5-nitro-2-(3-phenylpropyl-amino) benzoic acid (NPPB) uncouples mitochondria and increases the proton permeability of the plasma membrane in phagocytic cells.

    abstract::We present evidence that the potent chloride channel blocker NPPB has protonophoric activity in the mitochondria and across the plasma membrane of phagocytic cells. The resting O2 consumption of murine peritoneal macrophages was stimulated up to 2.5-fold in the presence of NPPB, with a K0.5 of 15 microM. The stimulato...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(91)80992-c

    authors: Lukacs GL,Nanda A,Rotstein OD,Grinstein S

    更新日期:1991-08-19 00:00:00

  • Effect of temperature on the role of Hsp104 and trehalose in barotolerance of Saccharomyces cerevisiae.

    abstract::We have studied the effect of temperature on the contribution of Hsp104 and trehalose to barotolerance using mutants deficient in Hsp104 and trehalose synthesis. When compared with a corresponding wild type strain, mutants of Hsp104 did not show temperature dependent barotolerance when the incubation temperature durin...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/s0014-5793(97)01141-1

    authors: Iwahashi H,Obuchi K,Fujii S,Komatsu Y

    更新日期:1997-10-13 00:00:00

  • Hetero-oligomerization of adenosine A1 receptors with P2Y1 receptors in rat brains.

    abstract::Adenosine and ATP modulate cellular and tissue functions via specific P1 and P2 receptors, respectively. Although, in general, adenosine inhibits excitability and ATP functions as an excitatory transmitter in the central nervous system, little is known about the direct interaction between P1 and P2 receptors. We recen...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/s0014-5793(02)03540-8

    authors: Yoshioka K,Hosoda R,Kuroda Y,Nakata H

    更新日期:2002-11-06 00:00:00

  • MALAT-1 interacts with hnRNP C in cell cycle regulation.

    abstract::As a conserved non-coding RNA gene, transcripts of MALAT-1 localize predominately in the nucleus. However in G2/M cell cycle phase, MALAT-1 transcripts were surprisingly found to translocate from the nucleus into the cytoplasm. Investigation also found that in this process MALAT-1 interacts with an abundant nuclear fa...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/j.febslet.2013.07.048

    authors: Yang F,Yi F,Han X,Du Q,Liang Z

    更新日期:2013-10-01 00:00:00

  • Bleomycin-reactive iron in patients with acute non-lymphocytic leukemia.

    abstract::Bleomycin-reactive iron was detected in the sera of six out of nine adults undergoing intensive chemotherapy for acute non-lymphocytic leukemia. In these individuals the corresponding transferrin saturation ranged from 96% to 113% and the serum ferritin from 775 to 9975 micrograms/l. Nontransferrin-bound iron has been...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(92)81037-m

    authors: Gordeuk VR,Brittenham GM

    更新日期:1992-08-10 00:00:00

  • Growth factor receptors in helminth parasites: signalling and host-parasite relationships.

    abstract::Parasitic helminths remain major pathogens of both humans and animals throughout the world. The success of helminth infections depends on the capacity of the parasite to counteract host immune responses but also to exploit host-derived signal molecules for its development. Recent progress has been made in the characte...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.febslet.2006.03.046

    authors: Dissous C,Khayath N,Vicogne J,Capron M

    更新日期:2006-05-22 00:00:00

  • Co-operative regulation of endocytosis by three Rab5 isoforms.

    abstract::Rab proteins are small GTPases involved in the regulation of membrane traffic. Rab5a has been shown to regulate transport in the early endocytic pathway. Here we report the isolation of cDNA clones encoding two highly related isoforms, Rab5b and Rab5c. The two proteins share with Rab5a all the structural features requ...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(95)00477-q

    authors: Bucci C,Lütcke A,Steele-Mortimer O,Olkkonen VM,Dupree P,Chiariello M,Bruni CB,Simons K,Zerial M

    更新日期:1995-06-05 00:00:00

  • Chronic lung inflammation in aging mice.

    abstract::To determine whether aging is associated with a pro-inflammatory shift in the lung, inflammation and inflammation-related gene expression in the lungs of 12-week-old and 24-month-old Balb/c mice were studied. cDNA microarray and quantitative reverse transcription-polymerase chain reaction analyses showed that eight in...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/j.febslet.2007.06.075

    authors: Aoshiba K,Nagai A

    更新日期:2007-07-24 00:00:00

  • Two distinct classes of rat intestinal mucosal enzymes incorporating putrescine into protein.

    abstract::Tissue-transglutaminase (t-TGase) is a family of calcium-dependent enzymes. A Ca2+-independent soluble enzyme, in addition to t-TGase, capable of incorporating polyamines into proteins was demonstrated in rat intestinal mucosa. The Ca2+-independent enzyme was stimulated 2- to 5-fold by Fe2+ and Co2+ ions but inhibited...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/s0014-5793(98)01062-x

    authors: Tsai YH,Lai WF,Wu YW,Johnson LR

    更新日期:1998-09-18 00:00:00

  • Regulation of cell surface GLUT1, GLUT3, and GLUT4 by insulin and IGF-I in L6 myotubes.

    abstract::The effects of insulin and IGF-I on the cell surface quantities of GLUT1, GLUT3 and GLUT4 glucose transporters in L6 myotubes were determined with the exofacial bis-mannose phololabel (ATB-BMPA). In basal cells, an equal molar quantity of each transporter isoform was found at the cell surface. Insulin stimulated the t...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(95)00589-2

    authors: Wilson CM,Mitsumoto Y,Maher F,Klip A

    更新日期:1995-07-10 00:00:00

  • Molecular evolution of the calmodulin gene.

    abstract::On the basis of the intron/exon organization and the intramolecular homology of DNA sequences, I propose a novel model for genesis of the calmodulin gene. A primordial calmodulin gene consisting of 51 base pairs (17 amino acids) was subjected to three-fold duplication to create modern calmodulin with four calcium-bind...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(87)80661-0

    authors: Nojima H

    更新日期:1987-06-15 00:00:00

  • Golgi stress response and organelle zones.

    abstract::Organelles have been studied traditionally as single units, but a novel concept is now emerging: each organelle has distinct functional zones that regulate specific functions. The Golgi apparatus seems to have various zones, including zones for: glycosylphosphatidylinositol-anchored proteins; proteoglycan, mucin and l...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审

    doi:10.1002/1873-3468.13554

    authors: Sasaki K,Yoshida H

    更新日期:2019-09-01 00:00:00

  • Visualizing dynamic actin cross-linking processes driven by the actin-binding protein anillin.

    abstract::Anillin is a type of actin filament cross-linking protein that stabilizes the actin-based contractile ring during cytokinesis. To elucidate the underlying intermolecular interactions between actin filaments and anillin, we utilized total internal reflection fluorescence microscopy (TIRFM) and high-speed atomic force m...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1002/1873-3468.13720

    authors: Matsuda K,Sugawa M,Yamagishi M,Kodera N,Yajima J

    更新日期:2020-04-01 00:00:00

  • Transcriptional regulation of murine NADP(+)-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase-synthetase.

    abstract::The cytosolic NADP(+)-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase is ubiquitously expressed in all mouse tissues and cell lines examined. Northern analyses of the RNA indicated that there is an extensive variation in the levels of mRNA in ...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(91)81354-b

    authors: Peri KG,MacKenzie RE

    更新日期:1991-12-02 00:00:00

  • Capsular polysaccharide production and serum survival of Vibrio vulnificus are dependent on antitermination control by RfaH.

    abstract::The human pathogen Vibrio vulnificus undergoes phase variation among colonial morphotypes, including a virulent opaque form which produces capsular polysaccharide (CPS) and a translucent phenotype that produces little or no CPS and is attenuated. Here, we found that a V. vulnificus mutant defective for RfaH antitermin...

    journal_title:FEBS letters

    pub_type: 信件

    doi:10.1002/1873-3468.12490

    authors: Garrett SB,Garrison-Schilling KL,Cooke JT,Pettis GS

    更新日期:2016-12-01 00:00:00

  • A novel antimicrobial peptide from the loach, Misgurnus anguillicaudatus.

    abstract::A novel antimicrobial peptide, named misgurin, was isolated and characterized from the loach (mudfish), Misgurnus anguillicaudatus. The 21-amino-acid peptide with a molecular mass of 2502 Da was purified to homogeneity using a heparin-affinity column and C18 reverse-phase and gel-permeation high-performance liquid chr...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/s0014-5793(97)00684-4

    authors: Park CB,Lee JH,Park IY,Kim MS,Kim SC

    更新日期:1997-07-14 00:00:00

  • The hinge region of chicken annexin I contains no site for tyrosine phosphorylation.

    abstract::Annexin I (AnxI) is a calcium-dependent membrane binding protein which has been implicated in various physiological activities. The region of the chicken anxI cDNA encoding the first 130 amino terminal residues was cloned by reverse transcription PCR in order to determine the relationship of its variable amino-termina...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(93)80241-l

    authors: Sidis Y,Horseman ND

    更新日期:1993-08-30 00:00:00

  • A crystallographic approach to DNA bending: prediction of nucleosome formation by DNA triple repeats and other repetitive sequences.

    abstract::DNA bending is due to two main factors: the inherent curvature of the sequence and its flexibility. Most methods of analysis do not allow a differentiation between these two factors. In this paper I show that the flexibility of DNA sequences can be estimated from the standard deviation of roll values determined by X-r...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/s0014-5793(97)01317-3

    authors: Subirana JA

    更新日期:1997-11-17 00:00:00

  • The cytochrome bc1 complex as an antipathogenic target.

    abstract::The cytochrome bc1 complex is a key component of the mitochondrial respiratory chains of many eukaryotic microorganisms that are pathogenic for plants or humans, such as fungi responsible for crop diseases and Plasmodium falciparum, which causes human malaria. Cytochrome bc1 is an enzyme that contains two (ubi)quinone...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审

    doi:10.1002/1873-3468.13868

    authors: Fisher N,Meunier B,Biagini GA

    更新日期:2020-09-01 00:00:00

  • GATA-3 suppresses IFN-gamma promoter activity independently of binding to cis-regulatory elements.

    abstract::The regulatory mechanism by which GATA-3 suppresses IFN-gamma gene expression was investigated. A reduction of GATA-3 using RNA interference technology enhanced, whereas overexpression of GATA-3 suppressed IFN-gamma mRNA expression. IL-4 expression was reciprocally affected by GATA-3. GATA-3-mediated down-regulation o...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/j.febslet.2004.06.026

    authors: Kaminuma O,Kitamura F,Kitamura N,Miyagishi M,Taira K,Yamamoto K,Miura O,Miyatake S

    更新日期:2004-07-16 00:00:00

  • Characterization of topoisomerase II-DNA interaction and identification of a DNA-binding domain by ultraviolet laser crosslinking.

    abstract::We have used ultraviolet laser crosslinking to characterize the DNA-binding properties of highly purified yeast topoisomerase II in the absence of ATP. A single 5 ns, 20 mJ pulse of 266 nm light produced optimal crosslinking to a short DNA duplex, with an efficiency of 0.25%. An equilibrium binding constant (Keq) of 1...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(96)00035-x

    authors: Hung F,Luo D,Sauvé DM,Muller MT,Roberge M

    更新日期:1996-02-12 00:00:00

  • Modulation of AP-1 activity by nitric oxide (NO) in vitro: NO-mediated modulation of AP-1.

    abstract::To understand the role of nitric oxide (NO) in controlling the specific DNA-binding activities of transcriptional factors, we investigated the in vitro effect of the NO-donor sodium nitroprusside (SNP) on the AP-1 activity of cultured mouse cerebellar granule cells. A gel-mobility assay showed that SNP inhibited AP-1 ...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(94)00839-6

    authors: Tabuchi A,Sano K,Oh E,Tsuchiya T,Tsuda M

    更新日期:1994-08-29 00:00:00

  • Stable expression of high affinity NK1 (substance P) and NK2 (neurokinin A) receptors but low affinity NK3 (neurokinin B) receptors in transfected CHO cells.

    abstract::Stable CHO cell clones which selectively express all three rat tachykinin receptors were established by transfection. The binding of radiolabled substance P and neurokinin A (substance K) to CHO clones expressing the NK1 and NK2 receptors, respectively, were saturatable and of high affinity (Kd = 0.17 nM (NK1); 3.4 nM...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(92)80295-r

    authors: Gether U,Marray T,Schwartz TW,Johansen TE

    更新日期:1992-01-27 00:00:00