Abstract:
:We have studied the action of an alpha-latrotoxin (alpha-LTX) complex of two polypeptides (LTX 130 kDa and low molecular weight protein (LMWP) 8 kDa) and the action of a venom fraction containing LTX with excess LMWP on calcium influx into synaptosomes and PC12 cells as well as on [14C]GABA release from synaptosomes. Both preparations considerably activate calcium influx and stimulate [14C]GABA release from synaptosomes. Preincubation of both preparations with antibodies against a 14 amino acid residue C-terminal peptide of LMWP differentially modulates these effects. Antibodies inhibit induced calcium influx and enhance induced GABA release.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Grishin EV,Himmelreich NH,Pluzhnikov KA,Pozdnyakova NG,Storchak LG,Volkova TM,Woll PGdoi
10.1016/0014-5793(93)80803-3subject
Has Abstractpub_date
1993-12-27 00:00:00pages
205-7issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(93)80803-3journal_volume
336pub_type
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