Abstract:
:Homologues of the catalase-peroxidase gene katG and the gene for the non-specific DNA binding protein dpsA were identified downstream of oxyR in Burkholderia pseudomallei. Northern experiments revealed that both katG and dpsA are co-transcribed during oxidative stress. Under conditions where the katG promoter is not highly induced, dpsA is transcribed from a second promoter located within the katG-dpsA intergenic region. A katG insertion mutant was found to be hypersensitive to various oxidants. Analysis of katG expression in the oxyR mutant indicates that OxyR is a dual function regulator that represses the expression of katG during normal growth and activates katG during exposure to oxidative stress. Both reduced and oxidized OxyR were shown to bind to the katG promoter.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Loprasert S,Whangsuk W,Sallabhan R,Mongkolsuk Sdoi
10.1016/s0014-5793(03)00328-4keywords:
subject
Has Abstractpub_date
2003-05-08 00:00:00pages
17-21issue
1-3eissn
0014-5793issn
1873-3468pii
S0014579303003284journal_volume
542pub_type
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