Abstract:
:The structure of [Val1]gramicidin A incorporated into sodium dodecyl-d25 sulphate micelles has been studied by two-dimensional proton NMR spectroscopy. Analysis of nuclear Overhauser effects, spin-spin couplings and solvent accessibility of NH groups show that the conformation of the Na+ complex of gramicidin A in detergent micelles, which in many ways mimic the phospholipid bilayer of biomembranes, is an N-terminal to N-terminal (head-to-head) dimer (Formula: see text) formed by two right-handed, single-stranded beta 6.3 helices with 6.3 residues per turn, differing from Urry's structure by handedness of the helices.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Arseniev AS,Barsukov IL,Bystrov VF,Lomize AL,Ovchinnikov YuAdoi
10.1016/0014-5793(85)80702-xsubject
Has Abstractpub_date
1985-07-08 00:00:00pages
168-74issue
2eissn
0014-5793issn
1873-3468journal_volume
186pub_type
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