Abstract:
:It is now widely recognized that the packaging of genomic DNA, together with core histones, linker histones, and other functional proteins into chromatin profoundly influences nuclear processes such as transcription, replication, DNA repair, and recombination. Whereas earlier structural studies portrayed nucleosomes (the basic repeating unit of chromatin) as monolithic and static macromolecular assemblies, we now know that they are highly dynamic and capable of extensive crosstalk with the cellular machinery. Histone variants have evolved to locally alter chromatin structure, whereas histone chaperones and other cellular factors promote histone exchange and chromatin fluidity. Both of these phenomena likely facilitate interconversion between different chromatin states that show varying degrees of transcriptional activity.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Chakravarthy S,Park YJ,Chodaparambil J,Edayathumangalam RS,Luger Kdoi
10.1016/j.febslet.2004.11.030keywords:
subject
Has Abstractpub_date
2005-02-07 00:00:00pages
895-8issue
4eissn
0014-5793issn
1873-3468pii
S0014-5793(04)01400-0journal_volume
579pub_type
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