Abstract:
:Saccharomyces cerevisiae mutant strain DTY26, lacking ACE1, the protein mediator for the induction of metallothionein gene expression, is unable to increase Cu,Zn superoxide dismutase mRNA in response to copper. In the wild-type strain DTY22 transcription of both Cu,Zn superoxide dismutase and metallothionein genes is induced by copper and silver, as expected on the basis of previous results indicating that ACE1 binds only Ag(I) besides Cu(I). We conclude that at the transcriptional level Cu,ZnSOD is co-regulated with metallothionein. Furthermore, structural similarities between the two promoters were found, which could explain the co-regulation effect and the quantitative differences in the response of the two genes to copper.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Carri MT,Galiazzo F,Ciriolo MR,Rotilio Gdoi
10.1016/0014-5793(91)80131-lsubject
Has Abstractpub_date
1991-01-28 00:00:00pages
263-6issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(91)80131-Ljournal_volume
278pub_type
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