Abstract:
:The effects of anaphylatoxin C3a on human neutrophils were studied in comparison with C5a. Both peptides induced a transient shape change response and a respiratory burst. In both cases C3a was 50- to 100-times less potent than C5a. A marked chemotactic response with bimodal concentration dependence was obtained with C5a, but no neutrophil chemotaxis was observed with C3a. Repeated stimulation led to homologous desensitization of shape changes and respiratory burst but no cross-desensitization, indicating that the two anaphylatoxins act through separate receptors. The lack of chemotactic activity suggests that C3a is not involved in neutrophil recruitment into infected or inflamed tissues.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Ehrengruber MU,Geiser T,Deranleau DAdoi
10.1016/0014-5793(94)00463-3subject
Has Abstractpub_date
1994-06-13 00:00:00pages
181-4issue
2-3eissn
0014-5793issn
1873-3468pii
0014-5793(94)00463-3journal_volume
346pub_type
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