Abstract:
:The potent inhibitors of protein kinase C (PKC), H7, staurosporine, and staurosporine derivatives, were examined for their inhibitory effects on novel PKC (nPKC) isozymes delta and epsilon. H7 and staurosporine, usually used as selective inhibitors of PKC, showed similar inhibitory effects on cPKC (a mixture of cPKC alpha, beta, and gamma) and nPKC delta and epsilon. The inhibitory effects of K252a, a non-selective protein kinase inhibitor, on cPKC was 3.2- and 22-fold higher than those on nPKC epsilon and delta, respectively. The staurosporine derivatives UCN-01 and UCN-01-Me also showed selective inhibition of cPKC.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Mizuno K,Saido TC,Ohno S,Tamaoki T,Suzuki Kdoi
10.1016/0014-5793(93)80254-rsubject
Has Abstractpub_date
1993-09-13 00:00:00pages
114-6issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(93)80254-Rjournal_volume
330pub_type
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