Specific inhibition of human beta-D-glucuronidase and alpha-L-iduronidase by a trihydroxy pipecolic acid of plant origin.

Abstract:

:The glucuronic acid analogue of 1-deoxynojirimycin, 2(S)-carboxy-3(R), 4(R), 5(S)-trihydroxypiperidine, recently isolated from seeds of Baphia racemosa, is a novel specific inhibitor of human liver beta-D-glucuronidase and alpha-L-iduronidase. No other glycosidases are inhibited. The inhibition of beta-D-glucuronidase is competitive, with a Ki of 8 X 10(-5) M and is pH-dependent. This inhibitor may be useful to induce a mucopolysaccharidosis or to investigate the function of microsomal beta-D-glucuronidase.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Cenci di Bello I,Dorling P,Fellows L,Winchester B

doi

10.1016/0014-5793(84)80911-4

subject

Has Abstract

pub_date

1984-10-15 00:00:00

pages

61-4

issue

1

eissn

0014-5793

issn

1873-3468

journal_volume

176

pub_type

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