Abstract:
:The glucuronic acid analogue of 1-deoxynojirimycin, 2(S)-carboxy-3(R), 4(R), 5(S)-trihydroxypiperidine, recently isolated from seeds of Baphia racemosa, is a novel specific inhibitor of human liver beta-D-glucuronidase and alpha-L-iduronidase. No other glycosidases are inhibited. The inhibition of beta-D-glucuronidase is competitive, with a Ki of 8 X 10(-5) M and is pH-dependent. This inhibitor may be useful to induce a mucopolysaccharidosis or to investigate the function of microsomal beta-D-glucuronidase.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Cenci di Bello I,Dorling P,Fellows L,Winchester Bdoi
10.1016/0014-5793(84)80911-4subject
Has Abstractpub_date
1984-10-15 00:00:00pages
61-4issue
1eissn
0014-5793issn
1873-3468journal_volume
176pub_type
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