Abstract:
:Studies were undertaken to further elucidate the mechanism(s) by which bradykinin-dependent phosphoinositide metabolism takes place in neuroblastoma X glioma hybrid NG108-15 cells [(1984) J. Biol. Chem. 259, 10201-10207] using [3H]inositol-labelled cells. Bradykinin produced net increases in the level of [3H]inositol phosphates, especially of [3H]inositol trisphosphate which is formed transiently and most rapidly. The results indicate that bradykinin activates a phosphodiesterase to break down phosphatidylinositol 4,5-bisphosphate, generating two recently recognized intracellular messengers, 1,2-diacylglycerol and inositol trisphosphate.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Yano K,Higashida H,Hattori H,Nozawa Ydoi
10.1016/0014-5793(85)80301-xsubject
Has Abstractpub_date
1985-02-25 00:00:00pages
403-6issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(85)80301-Xjournal_volume
181pub_type
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