Abstract:
:The malaria parasite has for long been thought to escape host complement attack as a survival strategy. However, it was only recently that complement evasion mechanisms of the parasite were described. Simultaneously, the role of complement in antibody-mediated naturally acquired and vaccine-induced protection against malaria has also been reported. Such findings should be considered in future vaccine design, given the current need to develop more efficacious vaccines against malaria. Parasite antigens derived from molecules mediating functions crucial for parasite survival, such as complement evasion, or parasite antigens against which antibody responses lead to an efficient complement attack could present new candidates for vaccines. In this review, we discuss recent findings on complement evasion by the malaria parasites and the emerging role of complement in antibody-mediated protection against malaria. We emphasize that immune responses to vaccines based on complement inhibitors should not only induce complement-activating antibodies but also neutralize the escape mechanisms of the parasite.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kiyuka PK,Meri S,Khattab Adoi
10.1002/1873-3468.13772subject
Has Abstractpub_date
2020-08-01 00:00:00pages
2502-2517issue
16eissn
0014-5793issn
1873-3468journal_volume
594pub_type
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