Protective effect of acetyl-L-carnitine against oxidative stress induced by antiretroviral drugs.

Abstract:

:Both HIV infection per se and antiretroviral drugs might contribute to oxidative stress and mitochondrial dysfunctions. In this study we assess zidovudine, stavudine and didanosine on U937 and CEM cell lines. All these drugs induced apoptosis and increased intracellular hydrogen peroxide but not superoxide anions. The addition of acetyl-l-carnitine (ALC) was able to prevent the pro-oxidant effect of the drugs tested. Supplementation with ALC, deficient in certain cohorts of HIV-infected individuals, especially on high active antiretroviral therapy regimen, has been associated with favourable effects. These data suggest that one of these effects could be a direct anti-oxidant action.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Ferraresi R,Troiano L,Roat E,Nemes E,Lugli E,Nasi M,Pinti M,Calvani M,Iannuccelli M,Cossarizza A

doi

10.1016/j.febslet.2006.11.016

subject

Has Abstract

pub_date

2006-12-11 00:00:00

pages

6612-6

issue

28-29

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(06)01332-9

journal_volume

580

pub_type

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