Abstract:
:When acquiring internal membranes and vesicular transport, eukaryotic cells started to synthesize sphingolipids and sterols. The physical differences between these and the glycerophospholipids must have enabled the cells to segregate lipids in the membrane plane. Localizing this event to the Golgi then allowed them to create membranes of different lipid composition, notably a thin, flexible ER membrane, consisting of glycerolipids, and a sturdy plasma membrane containing at least 50% sphingolipids and sterols. Besides sorting membrane proteins, in the course of evolution the simple sphingolipids obtained key positions in cellular physiology by developing specific interactions with (membrane) proteins involved in the execution and control of signaling. The few signaling sphingolipids in mammals must provide basic transmission principles that evolution has built upon for organizing the specific regulatory pathways tuned to the needs of the different cell types in the body.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
van Meer G,Hoetzl Sdoi
10.1016/j.febslet.2009.10.020subject
Has Abstractpub_date
2010-05-03 00:00:00pages
1800-5issue
9eissn
0014-5793issn
1873-3468pii
S0014-5793(09)00792-3journal_volume
584pub_type
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