Abstract:
:MicroRNA (miRNA) play a pivotal role in the development of liver fibrosis. However, the functions of miRNA in hepatitis C virus (HCV)-related liver fibrosis remain unclear. In this study, we systematically analyzed the microarray data of the serum miRNA in patients with HCV-induced hepatic fibrosis. Among 41 dysregulated miRNA, miR-1273g-3p was the most significantly upregulated miRNA and correlated with the stage of liver fibrosis. Overexpression of miR-1273g-3p could inhibit translation of PTEN, increase the expression of α-SMA, Col1A1, and reduce apoptosis in HSCs. Hence, we conclude that miR-1273g-3p might affect the activation and apoptosis of HSCs by directly targeting PTEN in HCV-related liver fibrosis.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Niu X,Fu N,Du J,Wang R,Wang Y,Zhao S,Du H,Wang B,Zhang Y,Sun D,Nan Ydoi
10.1002/1873-3468.12309subject
Has Abstractpub_date
2016-08-01 00:00:00pages
2709-24issue
16eissn
0014-5793issn
1873-3468journal_volume
590pub_type
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