Abstract:
:Cyclin B is a central regulator of transition from the G(2) phase of the cell cycle to mitosis. In mammalian cells two B-type cyclins have been characterised, cyclin B1 and B2. Both are expressed with a maximum in G(2) and their synthesis is mainly regulated on the transcriptional level. We show that a single cell cycle genes homology region, lacking a functional cell cycle-dependent element in tandem with it, contributes most of the cell cycle-dependent transcription from the cyclin B1 promoter. The coactivator p300 binds to the cyclin B1 promoter and synergises with the transcription factor NF-Y in activating transcription of cyclin B1.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Wasner M,Tschöp K,Spiesbach K,Haugwitz U,Johne C,Mössner J,Mantovani R,Engeland Kdoi
10.1016/s0014-5793(03)00028-0keywords:
subject
Has Abstractpub_date
2003-02-11 00:00:00pages
66-70issue
1-3eissn
0014-5793issn
1873-3468pii
S0014579303000280journal_volume
536pub_type
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