Abstract:
:The 23-residue synthetic peptide representing the N-terminus of HIV-1 gp41 is known to induce either leakage or fusion of lipid vesicles depending on the experimental conditions. In this paper we report that a polar amino acid substitution V-->E at position 2, known to block gp41 activity in vivo, makes the peptide unable to destabilize and/or fuse membranes. Moreover this variant, unlike the parent peptide, is never found in the membrane-associated beta conformation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Pereira FB,Goñi FM,Nieva JLdoi
10.1016/0014-5793(95)00257-asubject
Has Abstractpub_date
1995-04-03 00:00:00pages
243-6issue
2eissn
0014-5793issn
1873-3468pii
001457939500257Ajournal_volume
362pub_type
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