Abstract:
:The chemokine RANTES is a potent chemoattractant for eosinophils. RANTES is produced by lung epithelial cells during eosinophil-rich inflammatory diseases such as asthma. In this study, we examined the effects of thiazolidinediones (TZD) on RANTES expression in a human lung epithelial cell line, A549. In A549 cells, interleukin-1beta and tumor necrosis factor-alpha induced endogenous RANTES protein secretion, mRNA expression, and promoter activity. The TZD inhibited these effects. Our data indicate that the suppression of the expression of RANTES can be accomplished by TZD treatment, raising the possibility that TZD might be of therapeutic value in diseases such as asthma.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Momoi A,Murao K,Imachi H,Sayo Y,Nakamura H,Hosokawa H,Sato M,Fujita J,Okada H,Ishida T,Takahara Jdoi
10.1016/s0014-5793(99)00678-xkeywords:
subject
Has Abstractpub_date
1999-06-11 00:00:00pages
301-4issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(99)00678-Xjournal_volume
452pub_type
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