Thiazolidinedione inhibits production of RANTES in a cytokine-treated human lung epithelial cell line.

Abstract:

:The chemokine RANTES is a potent chemoattractant for eosinophils. RANTES is produced by lung epithelial cells during eosinophil-rich inflammatory diseases such as asthma. In this study, we examined the effects of thiazolidinediones (TZD) on RANTES expression in a human lung epithelial cell line, A549. In A549 cells, interleukin-1beta and tumor necrosis factor-alpha induced endogenous RANTES protein secretion, mRNA expression, and promoter activity. The TZD inhibited these effects. Our data indicate that the suppression of the expression of RANTES can be accomplished by TZD treatment, raising the possibility that TZD might be of therapeutic value in diseases such as asthma.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Momoi A,Murao K,Imachi H,Sayo Y,Nakamura H,Hosokawa H,Sato M,Fujita J,Okada H,Ishida T,Takahara J

doi

10.1016/s0014-5793(99)00678-x

keywords:

subject

Has Abstract

pub_date

1999-06-11 00:00:00

pages

301-4

issue

3

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(99)00678-X

journal_volume

452

pub_type

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