Abstract:
:Protein kinases play a crucial role in the regulation of cellular processes. Most eukaryotes reserve about 2.5% of their genes for protein kinases. We analysed the genome of the single-celled ciliate Paramecium tetraurelia and identified 2606 kinases, about 6.6% of its genes, representing the largest kinome to date. A gene tree combined with human kinases revealed a massive expansion of the calcium calmodulin regulated subfamily, underlining the importance of calcium in the physiology of P. tetraurelia. The kinases are embedded in only 40 domain architectures, contrasting 134 in human. This might indicate different mechanisms to achieve target specificity.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Bemm F,Schwarz R,Förster F,Schultz Jdoi
10.1016/j.febslet.2009.10.029subject
Has Abstractpub_date
2009-11-19 00:00:00pages
3589-92issue
22eissn
0014-5793issn
1873-3468pii
S0014-5793(09)00805-9journal_volume
583pub_type
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