Abstract:
:Anthrax is a severe bacterial infection that occurs when Bacillus anthracis spores gain access into the body and germinate in macrophages, causing septicemia and toxemia. Anthrax toxin is a binary A-B toxin composed of protective antigen (PA), lethal factor (LF), and edema factor (EF). PA mediates the entry of either LF or EF into the cytosol of host cells. LF is a zinc metalloprotease that inactivates mitogen-activated protein kinase kinase inducing cell death, and EF is an adenylyl cyclase impairing host defences. Inhibitors targeting different steps of toxin activity have recently been developed. Anthrax toxin has also been exploited as a therapeutic agent against cancer.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Ascenzi P,Visca P,Ippolito G,Spallarossa A,Bolognesi M,Montecucco Cdoi
10.1016/s0014-5793(02)03609-8keywords:
subject
Has Abstractpub_date
2002-11-20 00:00:00pages
384-8issue
3eissn
0014-5793issn
1873-3468pii
S0014579302036098journal_volume
531pub_type
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