Abstract:
:The degradation of type IX collagen, a minor collagen in cartilage, was examined by treatment with three different types of matrix metalloproteinases (MMPs) purified from the culture medium of rheumatoid synovial cells. Neither MMP-1 (collagenase) nor MMP-2 (so-called 'gelatinase') could digest type IX collagen, but MMP-3 (stromelysin) readily degraded it into smaller fragments. This suggests that MMP-3 may be responsible for the pathological degradation and/or normal turnover of type IX collagen.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Okada Y,Konomi H,Yada T,Kimata K,Nagase Hdoi
10.1016/0014-5793(89)80586-1subject
Has Abstractpub_date
1989-02-27 00:00:00pages
473-6issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(89)80586-1journal_volume
244pub_type
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