Abstract:
:Superoxide reacts with nitric oxide to form peroxynitrite, a potent oxidising agent which may contribute to tissue damage in pathological situations such as inflammation and ischaemia/reperfusion. One mechanism by which oxidative stress damages tissues is the induction of a specific Cyclosporin A-sensitive mitochondrial calcium efflux pathway. Here we show that peroxynitrite induces calcium efflux from mammalian mitochondria and that this efflux is blocked by Cyclosporin A. These data suggest that disruption of mitochondrial calcium efflux may contribute to tissue damage when superoxide and nitric oxide are present together in vivo.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Packer MA,Murphy MPdoi
10.1016/0014-5793(94)00461-7subject
Has Abstractpub_date
1994-05-30 00:00:00pages
237-40issue
2-3eissn
0014-5793issn
1873-3468pii
0014-5793(94)00461-7journal_volume
345pub_type
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