Peroxynitrite causes calcium efflux from mitochondria which is prevented by Cyclosporin A.

Abstract:

:Superoxide reacts with nitric oxide to form peroxynitrite, a potent oxidising agent which may contribute to tissue damage in pathological situations such as inflammation and ischaemia/reperfusion. One mechanism by which oxidative stress damages tissues is the induction of a specific Cyclosporin A-sensitive mitochondrial calcium efflux pathway. Here we show that peroxynitrite induces calcium efflux from mammalian mitochondria and that this efflux is blocked by Cyclosporin A. These data suggest that disruption of mitochondrial calcium efflux may contribute to tissue damage when superoxide and nitric oxide are present together in vivo.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Packer MA,Murphy MP

doi

10.1016/0014-5793(94)00461-7

subject

Has Abstract

pub_date

1994-05-30 00:00:00

pages

237-40

issue

2-3

eissn

0014-5793

issn

1873-3468

pii

0014-5793(94)00461-7

journal_volume

345

pub_type

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