Metal regulation of metallothionein participation in redox reactions.

Abstract:

:Like glutathione or dithiothreitol, metallothionein effects the formation of pancreatic ribonuclease A from its S-sulfonated derivative catalyzed by protein disulfide isomerase. EDTA increases the yield of ribonuclease A activity recovery with metallothionein but does not affect the reaction with glutathione or dithiothreitol. EDTA also increases the reactivity of thiol groups in metallothionein with 5,5'-dithiobis-(2-nitrobenzoic acid) by chelation of zinc ions. It is suggested that the thiol groups in metallothionein form a part of the pool of cellular thiols in the regulation of cellular redox reactions and their availability is modulated by zinc chelation.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Zhang S,Li J,Wang CC,Tsou CL

doi

10.1016/s0014-5793(99)01562-8

keywords:

subject

Has Abstract

pub_date

1999-12-03 00:00:00

pages

383-6

issue

3

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(99)01562-8

journal_volume

462

pub_type

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