Abstract:
:In rat cerebrocortical synaptosomes, the addition of 4 beta-phorbol dibutyrate (4 beta-PDBu) and arachidonic acid enhances and decreases, respectively, the glutamate release evoked by 4-aminopyridine. Pretreatment of synaptosomes with 12-O-tetradecanoylphorbol 13-acetate (TPA) or pre-incubation with staurosporine, prevent the stimulatory effect of 4 beta-PDBu, but are without effect on the inhibitory action of arachidonic acid. Moreover, methyl arachidonate, which is not effective as a PKC activator, also strongly inhibits glutamate exocytosis. These results suggest that PKC is not involved in the inhibition of glutamate release by arachidonic acid.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Herrero I,Miras-Portugal MT,Sánchez-Prieto Jdoi
10.1016/0014-5793(92)80312-5keywords:
subject
Has Abstractpub_date
1992-01-27 00:00:00pages
317-9issue
3eissn
0014-5793issn
1873-3468pii
0014-5793(92)80312-5journal_volume
296pub_type
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