Abstract:
:In addition to the classical functions of the Golgi in membrane transport and glycosylation, the Golgi apparatus of mammalian cells is now recognised to contribute to the regulation of a range of cellular processes, including mitosis, DNA repair, stress responses, autophagy, apoptosis and inflammation. These processes are often mediated, either directly or indirectly, by membrane scaffold molecules, such as golgins and GRASPs which are located on Golgi membranes. In many cases, these scaffold molecules also link the actin and microtubule cytoskeleton and influence Golgi morphology. An emerging theme is a strong relationship between the morphology of the Golgi and regulation of a variety of signalling pathways. Here, we review the molecular regulation of the morphology of the Golgi, especially the role of the golgins and other scaffolds in the interaction with the microtubule and actin networks. In addition, we discuss the impact of the modulation of the Golgi ribbon in various diseases, such as neurodegeneration and cancer, to the pathology of disease.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kulkarni-Gosavi P,Makhoul C,Gleeson PAdoi
10.1002/1873-3468.13567subject
Has Abstractpub_date
2019-09-01 00:00:00pages
2289-2305issue
17eissn
0014-5793issn
1873-3468journal_volume
593pub_type
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