Abstract:
:Hematopoietic progenitors have been shown to retain plasticity and switch lineages by appropriate stimuli. However, mature blood cells hardly showed such differentiation plasticity. In this paper, we tried to reprogram mature B cells into erythroid lineage by expressing various hematopoietic transcription factors. Among various factors, GATA-1, SCL together with CCAAT/enhancer binding protein (C/EBP) α turned out to be a minimal set of factors that efficiently reprogrammed terminally differentiated mature B cells into erythroid lineage, as evidenced by colony forming assays and erythroid-specific gene expressions. This study sets an avenue to generate autologous erythrocytes from peripheral B cells.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Sadahira K,Fukuchi Y,Kunimono H,Sakurai M,Ikeda Y,Okamoto S,Nakajima Hdoi
10.1016/j.febslet.2012.08.019subject
Has Abstractpub_date
2012-10-19 00:00:00pages
3645-52issue
20eissn
0014-5793issn
1873-3468pii
S0014-5793(12)00676-Xjournal_volume
586pub_type
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