Abstract:
:Intravenous injections of 25.5 nmol rat amylin into fasted anesthetized rats caused a rapid increase in plasma lactate followed by an increase in plasma glucose; there was a transient fall in blood pressure. Subcutaneous injection of 25.5 nmol amylin also caused increases in lactate and glucose but did not change blood pressure. Similar responses were observed during somatostatin infusion and in the absence of changes in catecholamines. These results fit with a scheme in which amylin elicits muscle glycogenolysis, release of lactate, and increased hepatic gluconeogenesis due to increased supply of substrate.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Young AA,Wang MW,Cooper GJdoi
10.1016/0014-5793(91)81113-msubject
Has Abstractpub_date
1991-10-07 00:00:00pages
101-4issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(91)81113-Mjournal_volume
291pub_type
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