Abstract:
:The number of muscarinic acetylcholine receptors (MAChRs), as detected by binding of [3H]quinuclidinyl benzilate (QNB), was investigated under conditions which promote protein phosphorylation. Incubation of a crude heart membrane preparation in the presence of ATP/Mg2+ reduced MAChR number by 50%. Incubation with polymyxin B, an inhibitor of protein kinase C, blocked the effect of ATP/Mg2+ and increased MAChR number by 74%.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Creazzo TL,Wrenn RWdoi
10.1016/0014-5793(88)81010-xsubject
Has Abstractpub_date
1988-12-19 00:00:00pages
175-7issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(88)81010-Xjournal_volume
242pub_type
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