Abstract:
:Under hypobaric hypoxia, antioxidant defenses of the heart are stressed by the enhanced production of ROS. Mammalian heart acclimatizes to hypoxia through altered gene expression, which we studied in murine heart exposed to 10h of acute hypobaric hypoxia (AHH), equivalent to 15000ft, using cDNA arrays. Functional classification of genes with a > or =2-fold change revealed a number of pro-oxidants like Cyba, Xdh, Txnip, Ppp1r15b and antioxidants like Cat, Gpx1, Mt1, Mgst1. Interestingly, the protein level of Cyba, a subunit of NADPH oxidase, was markedly decreased in AHH exposed heart, suggesting the involvement of some stress response pathways. The AHH exposure also caused a significant reduction (50%) in the level of GSH (P<0.05). The present study provides a retrospective insight on the cellular antioxidant defense mechanisms under AHH.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Karar J,Dolt KS,Mishra MK,Arif E,Javed S,Pasha MAdoi
10.1016/j.febslet.2007.08.044subject
Has Abstractpub_date
2007-10-02 00:00:00pages
4577-82issue
24eissn
0014-5793issn
1873-3468pii
S0014-5793(07)00921-0journal_volume
581pub_type
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