Abstract:
:The activity of breast milk BSDL was assayed with or without phospholipids as extra-intestinal effector candidates. Phosphatidic acid, lysophosphatidic acid and platelet activating factor but not phosphatidylcholine and lysophosphatidylcholine stimulated BSDL activity at least as efficiently as taurocholate. The apparent dissociation constants of PA and LPA at saturating concentrations of three different substrates were between 0.1 and 13.4 μM and that of PAF was below or equal to 200 pM. Kinetic data suggested the existence of at least one binding site for each of these effectors. PA, LPA and PAF are likely extra-intestinal modulators of BSDL activity.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Fontbonne H,Puigserver A,Bouza B,Lombardo D,Ajandouz el Hdoi
10.1016/j.febslet.2013.07.020subject
Has Abstractpub_date
2013-09-17 00:00:00pages
3002-7issue
18eissn
0014-5793issn
1873-3468pii
S0014-5793(13)00549-8journal_volume
587pub_type
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