Abstract:
:Telomerase maintains the ends of eukaryotic chromosomes, and its activity is an important parameter correlating with the proliferative capacity of cells. We have investigated cell cycle-specific changes in telomerase activity using cultures of Desmodesmus quadricauda, a model alga naturally synchronized by light/dark entrainment. A quantitative telomerase assay revealed high activity in algal cultures, with slight changes during the light period. Significantly increased telomerase activity was observed at the end of the dark phase, when cell division was complete. In contrast to other models, a natural separation between nuclear and cellular division typical for the cell cycle in D. quadricauda made this observation possible.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Ševčíková T,Bišová K,Fojtová M,Lukešová A,Hrčková K,Sýkorová Edoi
10.1016/j.febslet.2013.01.058subject
Has Abstractpub_date
2013-03-18 00:00:00pages
743-8issue
6eissn
0014-5793issn
1873-3468pii
S0014-5793(13)00103-8journal_volume
587pub_type
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