Abstract:
:Using a variety of peptide analogues of oxytocin (OT) and Arg8-vasopressin (AVP), OT-mediated induction of urokinase-type plasminogen activator (uPA) was examined in LLC-PK1 renal epithelial cells, which possess distinct high-affinity receptors of both the OT- and vasopressin renal (V2-) types. OT or OT-receptor specific agonists induced concentration-dependent cAMP synthesis, activation of the cAMP-dependent protein kinase (cAMP-PK) and uPA production consistent with their respective binding affinities for the V2- and not the OT-receptor. OT-mediated uPA induction could be inhibited in a concentration-dependent fashion by coincubation with a V2/V1-receptor specific antagonist, but not by an OT-receptor specific antagonist. Results implied that stimulation of cAMP- and uPA responses in LLC-PK1 cells by OT was V2-receptor-mediated.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Jans DA,Pavo I,Fahrenholz Fdoi
10.1016/0014-5793(93)81149-tsubject
Has Abstractpub_date
1993-01-04 00:00:00pages
134-8issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(93)81149-Tjournal_volume
315pub_type
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