Abstract:
:A new approach is suggested for delineating the structural and functional amino acid residues in proteins with known three-dimensional structure, basing on the involvement of residues in intramolecular hydrophobic and hydrophilic interactions and additional information about the conservativity of the residues. The approach is applied to the families of homologous neurotoxins and cardiotoxins. The results obtained concerning the role of amino acid residues in both families of toxins accord well with the similarity of their fold, but different mechanisms of action. Current approach can be used for detailed characterization of protein spatial structures, as well as for rational protein engineering.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Golovanov AP,Efremov RG,Jaravine VA,Vergoten G,Arseniev ASdoi
10.1016/0014-5793(95)01212-wsubject
Has Abstractpub_date
1995-11-13 00:00:00pages
162-6issue
1-2eissn
0014-5793issn
1873-3468pii
0014-5793(95)01212-Wjournal_volume
375pub_type
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