Interaction of avidin with spin-labelled N-biotinyl phosphatidylethanolamine in a lipid membrane.

abstract：:Skeletal muscle plays key roles in metabolic homeostasis. Loss of muscle mass, called muscle atrophy exacerbates disease-associated metabolic perturbations. In this study, we characterized the molecular functions and mechanisms underlying regulation of skeletal muscle atrophy induced by denervation. Denervation signif...

journal_title：FEBS letters

authors： Kang J,Jeong MG,Oh S,Jang EJ,Kim HK,Hwang ES

更新日期：2014-01-03 00:00:00

abstract：:Immunometabolism focuses on the mechanisms regulating the impact of metabolism on lymphocyte activity and autoimmunity outbreak. The adipose tissue is long known to release adipokines, either pro- or anti-inflammatory factors bridging nutrition and immune function. More recently, adipocytes were discovered to also rel...

journal_title：FEBS letters

authors： de Candia P,De Rosa V,Gigantino V,Botti G,Ceriello A,Matarese G

更新日期：2017-10-01 00:00:00

abstract：:We have recently reported a neural variant of microtubule-associated protein 4 with a short pro-rich region (MAP4-SP). Here, we show that the neural MAP4 has reduced microtubule-stabilizing activity, compared to the ubiquitous MAP4 with a long pro-rich region (MAP4-LP), both in vitro and in vivo. Fluorescence recovery...

journal_title：FEBS letters

authors： Hasan MR,Jin M,Matsushima K,Miyamoto S,Kotani S,Nakagawa H

更新日期：2006-06-12 00:00:00

abstract：:The substrate peptide bond cleaved by cathepsins B and L is determined not by the amino acid contributing the carboxyl group to this bond as in the case of serine proteases but rather by the presence of a neighboring amino acid with a large hydrophobic side chain. From a study of the inhibitory potency in a series, Cb...

journal_title：FEBS letters

authors： Kirschke H,Wikstrom P,Shaw E

更新日期：1988-02-08 00:00:00

abstract：:Structural integrity may be needed for the glutathione-linked peroxidase activity of human ceruloplasmin. Intact human ceruloplasmin has a potent peroxidase property to decompose H2O2 in the presence of reduced glutathione. However, the fragment of approximately 116000 Da produced by proteolytic degradation had less t...

journal_title：FEBS letters

authors： Kim IG,Park SY

更新日期：1998-10-23 00:00:00

abstract：:The nucleocapsid (N) protein of SARS coronavirus (SARS_CoV) is a major structural component of virions, which appears to be a multifunctional protein involved in viral RNA replication and translation. Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is related to the pre-mRNA splicing in the nucleus and translati...

journal_title：FEBS letters

authors： Luo H,Chen Q,Chen J,Chen K,Shen X,Jiang H

更新日期：2005-05-09 00:00:00

abstract：:In unicellular species codon usage is determined by mutational biases and natural selection. Among prokaryotes, the influence of these factors is different if the genome is skewed towards AT or GC, since in AT-rich organisms translational selection is absent. On the other hand, in AT-rich unicellular eukaryotes the tw...

journal_title：FEBS letters

authors： Naya H,Romero H,Carels N,Zavala A,Musto H

更新日期：2001-07-20 00:00:00

abstract：:The protein kinase C activator, phorbol-12-myristate-13-acetate (PMA), augments the cyclic AMP accumulation induced by forskolin in pheochromocytoma (PC 12) cells with an EC50 value of 14 nM, while having no effect on basal values. At a concentration of 100 nM PMA markedly augmented the magnitude of the forskolin resp...

journal_title：FEBS letters

authors： Hollingsworth EB,Ukena D,Daly JW

更新日期：1986-02-03 00:00:00

abstract：:We have previously shown that topoisomerase I (topo I) antagonist inhibited retrovirus replication. Since tyrphostins, synthetic compounds and protein tyrosine kinases (PTKs) blockers, inhibited topo I activity (manuscript in preparation) we examined their ability to inhibit Moloney murine leukemia virus (Mo-MuLV) rep...

journal_title：FEBS letters

authors： Esther A,Iftach S,Esther P

更新日期：1994-03-14 00:00:00

abstract：:We studied the molecular mechanism underlying PDT-induced apoptosis-dependent macrophage activation, particularly through NO production. We demonstrate that NO production is initially induced by HSP70 on the apoptotic cell surface, and is further enhanced by macrophage phagocytosis. Additionally, we found that apoptot...

journal_title：FEBS letters

authors： Song S,Zhou F,Chen WR,Xing D

更新日期：2013-01-16 00:00:00

abstract：:A 13-residue peptide containing the first 12 amino acids of the N-terminal part of the signal sequence of yeast cytochrome c oxidase subunit IV is shown by chemical crosslinking to interact with a mitochondrial protein. This result is obtained with mitochondria from four different origins. Submitochondrial localizatio...

journal_title：FEBS letters

authors： Font B,Goldschmidt D,Chich JF,Thieffry M,Henry JP,Gautheron DC

更新日期：1991-02-11 00:00:00

abstract：:Ample evidence indicates that sphingosine-1-phosphate (SPP) can serve as an intracellular second messenger regulating calcium mobilization, and cell growth and survival. Moreover, the dynamic balance between levels of the sphingolipid metabolites, ceramide and SPP, and consequent regulation of opposing signaling pathw...

journal_title：FEBS letters

authors： Spiegel S,Milstien S

更新日期：2000-06-30 00:00:00

abstract：:SigT is an ECF sigma factor in Streptomyces coelicolor. sigT and its putative anti-sigma factor gene rstA are located in one putative operon, and SigT could physically interact with RstA. Deletion of sigT or rstA caused accelerated morphological development and enhanced production of antibiotics, concomitant with over...

journal_title：FEBS letters

authors： Mao XM,Zhou Z,Cheng LY,Hou XP,Guan WJ,Li YQ

更新日期：2009-10-06 00:00:00

abstract：:In this work, we investigated electron transport around the photosynthetic pigment-protein complex of Photosystem I (PS I) mediated by external high-potential electron carrier 2,3-dichloro-1,4-naphtoquinone (Cl2 NQ) and ascorbate. It has been demonstrated that the oxidized species of Cl2 NQ and ascorbate serve as inte...

journal_title：FEBS letters

authors： Petrova AA,Trubitsin BV,Boskhomdzhieva BK,Semenov AY,Tikhonov AN

更新日期：2018-07-01 00:00:00

abstract：:H2O2 addition to the oxidized cytochrome c oxidase reconstituted in liposomes brings about a red shift of the Soret band of the enzyme and an increased absorption in the visible region with two distinct peaks at approximately 570 and 605 nm. Throughout pH range 6-8.5, the spectral changes at 570 nm and in the Soret ba...

journal_title：FEBS letters

authors： Vygodina T,Konstantinov AA

更新日期：1987-07-27 00:00:00

abstract：:Recombinant cell lines expressing D2 and D3 dopamine receptor isoforms have been used to study coupling of these receptors to G-proteins from the effects of GTP to reduce agonist binding affinities in agonist/[3H]spiperone competition experiments. D2(short) expressed in Ltk- cells, D2(long) expressed in Ltk- or CHO ce...

journal_title：FEBS letters

authors： Castro SW,Strange PG

更新日期：1993-01-11 00:00:00

abstract：:32P-Labelled tRNA was isolated from uninfected and phage phi 149-infected Vibrio cholerae cells. These tRNA preparations were then hybridised with DNA isolated from phage phi 149. Significant hybridisation was observed only with tRNA from phage phi 149-infected cells. This strongly suggests that infection of classical...

journal_title：FEBS letters

authors： Ghosh RK,Guhathakurta I

更新日期：1983-10-03 00:00:00

abstract：:Although signal transducer and activator of transcription 1 (STAT1) mediated regulation of p53 transcription and apoptosis has been previously reported, modulation of other members of the p53 family of transcription factors remains poorly understood. In this study, we found that STAT1 and TA-p73 can interact directly ...

journal_title：FEBS letters

authors： Soond SM,Carroll C,Townsend PA,Sayan E,Melino G,Behrmann I,Knight RA,Latchman DS,Stephanou A

更新日期：2007-03-20 00:00:00

abstract：:Recent evidence indicates that cell-cycle regulating proteins are involved in apoptotic process in post-mitotic neurons. In this study, we examined cell-cycle regulators for G1/S cell-cycle progression after a transient focal cerebral ischemia induced by middle cerebral artery (MCA) occlusion. In the cerebral frontopa...

journal_title：FEBS letters

authors： Wen Y,Yang S,Liu R,Simpkins JW

更新日期：2005-08-29 00:00:00

abstract：:Intracellular Ca(2+) ([Ca(2+)](i)) changes were measured in cell bodies of cultured rat hippocampal neurones with the fluorescent indicator Fluo-3. In the absence of external Ca(2+), the cholinergic agonist carbachol (200 microM) and the sarcoendoplasmic reticulum Ca(2+) pump inhibitor thapsigargin (0.4 microM) both t...

journal_title：FEBS letters

authors： Bouron A

更新日期：2000-03-31 00:00:00

abstract：:We have raised monoclonal antibodies (Mab) to the Mr 55,000 desmin polypeptide, electrophoretically purified from cytoskeletal preparations of isolated bovine heart Purkinje fibers. One of the Mabs, 39AB6, revealed desmin only in cow Purkinje fibers and did not react with desmins from other muscle cells, including ven...

journal_title：FEBS letters

authors： Virtanen I,Närvänen O,Thornell LE

更新日期：1990-07-02 00:00:00

abstract：:Mitochondrial ATP synthase, a major ATP supplier in respiring cells, should be regulated in amount and in activity to respond to the varying demands of cells for ATP. We screened 80 protein kinase inhibitors and found that HeLa cells treated with four inhibitors exhibited reduced mitochondrial ATP synthesis activity. ...

journal_title：FEBS letters

authors： Sugawara K,Fujikawa M,Yoshida M

更新日期：2013-11-29 00:00:00

abstract：:Turnip yellow mosaic virus (TYMV) is a positive-strand RNA virus able to infect Arabidopsis thaliana. To establish a TYMV infection system in Arabidopsis cell culture, TYMV replicons with the capsid protein gene replaced by a reporter gene expressing the Sh ble protein conferring zeocin resistance were used to transfe...

journal_title：FEBS letters

authors： Camborde L,Tournier V,Noizet M,Jupin I

更新日期：2007-01-23 00:00:00

abstract：:Sequence comparison based on Hydrophobic Cluster Analysis procedures shows that the extracellular approximately 200 amino acids domains of cytokines receptors belonging to the Cytokine/Growth hormone/Prolactin receptor family and to the Interferon one are organized in two homologous subdomains. Further, comparison of ...

journal_title：FEBS letters

authors： Thoreau E,Petridou B,Kelly PA,Djiane J,Mornon JP

更新日期：1991-04-22 00:00:00

abstract：:The rat chromosomal gene for uricase was cloned. The gene spans more than 20 kilobases and the coding region is divided into 8 exons by 7 introns. The organization of the rat uricase gene is so greatly different from that of the soybean gene that the difference may not have been caused only by the removal of some ance...

journal_title：FEBS letters

authors： Motojima K,Goto S

更新日期：1990-05-07 00:00:00

abstract：:WW domains harbor substrates containing proline-rich motifs, but the substrate specificity and binding mechanism remain elusive for those WW domains less amenable for structural studies, such as human WWP2 (hWWP2). Herein we have employed multiple techniques to investigate the second WW domain (WW2) in hWWP2. Our resu...

journal_title：FEBS letters

authors： Jiang J,Wang N,Jiang Y,Tan H,Zheng J,Chen G,Jia Z

更新日期：2015-07-08 00:00:00

abstract：:Creutzfeldt-Jakob disease is a slow, infectious, progressive neurological disorder which results in human dementia. Synaptic membranes from various brain regions of guinea pigs infected with Creutzfeldt-Jakob disease show increased guanyl nucleotide- or 5-hydroxytryptamine-mediated activation of adenylate cyclase. Thi...

journal_title：FEBS letters

authors： Rasenick MM,Valley S,Manuelidis EE,Manuelidis L

更新日期：1986-03-17 00:00:00

abstract：:Stopped-flow kinetics showed that the inhibition of the lysosomal cysteine proteinase, cathepsin B, by its endogenous inhibitor, cystatin C, occurs by a two-step mechanism, in which an initial, weak interaction is followed by a conformational change. The initial interaction most likely involves binding of the N-termin...

journal_title：FEBS letters

authors： Nycander M,Estrada S,Mort JS,Abrahamson M,Björk I

更新日期：1998-01-23 00:00:00

abstract：:CDK11(p58), a 58kDa protein of the PITSLRE kinase family, plays an important role in cell cycle progression, and is closely related to cell apoptosis. To gain further insight into the function of CDK11(p58), we screened a human fetal liver cDNA library for its interacting proteins using the yeast two-hybrid system. He...

journal_title：FEBS letters

authors： Zong H,Li Z,Liu L,Hong Y,Yun X,Jiang J,Chi Y,Wang H,Shen X,Hu Y,Niu Z,Gu J

更新日期：2005-07-04 00:00:00

abstract：:Chemotherapy is a major anticancer therapeutic modality, however, multidrug resistance (MDR) is frequently observed and hinders treatment efficacy. Here, we investigated the role and potential mechanism of the long noncoding RNA (lncRNA) FENDRR in adriamycin resistance of chronic myeloid leukaemia (CML) cells. FENDRR ...

journal_title：FEBS letters

authors： Zhang F,Ni H,Li X,Liu H,Xi T,Zheng L

更新日期：2019-08-01 00:00:00