Abstract:
:A colostral proline-rich polypeptide complex (PRP) consisting of over 30 peptides shows beneficial effects in Alzheimer's disease (AD) patients when administered in the form of sublinqual tablets called Colostrinin. The aim of the present studies was to investigate whether nanopeptide fragment of PRP (NP) - one of the PRP complex components can affect aggregation of amyloid beta (Abeta1-42). The effect of NP on Abeta aggregation was studied using Thioflavin T (ThT) binding, atomic force microscopy, and analyzing circular dichroism spectra. Results presented suggest that NP can directly interact with amyloid beta, inhibit its aggregation and disrupt existing aggregates acting as a beta sheet breaker and reduce toxicity induced by aggregated forms of Abeta.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Janusz M,Woszczyna M,Lisowski M,Kubis A,Macała J,Gotszalk T,Lisowski Jdoi
10.1016/j.febslet.2008.11.053subject
Has Abstractpub_date
2009-01-05 00:00:00pages
190-6issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(08)00981-2journal_volume
583pub_type
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