Abstract:
:The effects of insulin and IGF-I on the cell surface quantities of GLUT1, GLUT3 and GLUT4 glucose transporters in L6 myotubes were determined with the exofacial bis-mannose phololabel (ATB-BMPA). In basal cells, an equal molar quantity of each transporter isoform was found at the cell surface. Insulin stimulated the translocation of all three glucose transporter isoforms to the plasma membrane fraction from the light microsome fraction, resulting in equal molar quantities on the cell surface. IGF-I stimulated a similar translocation of all isoforms, augmented by an increase in surface GLUT3 as assessed by ATB-BMPA.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Wilson CM,Mitsumoto Y,Maher F,Klip Adoi
10.1016/0014-5793(95)00589-2subject
Has Abstractpub_date
1995-07-10 00:00:00pages
19-22issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(95)00589-2journal_volume
368pub_type
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