Abstract:
:The cardiovascular system consists of many cell types with distinct embryonic origins. Cells from an Islet1 (Isl1)-expressing progenitor population make a substantial contribution to the developing heart. We reasoned that cells derived from Isl1-expressing progenitors might contribute more widely to the cardiovascular system. We show that cells derived from an Isl1-expressing progenitor lineage make a wide contribution to the systemic vasculature and that embryos conditionally deficient for Rac1 within this cell population develop defects in the non-cardiac vasculature. These data define new roles for Isl1 in the developing embryo and demonstrate a contribution of Isl1-expressing progenitors to vascular endothelium in vivo.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Keenan ID,Rhee HJ,Chaudhry B,Henderson DJdoi
10.1016/j.febslet.2012.05.014subject
Has Abstractpub_date
2012-06-21 00:00:00pages
1790-4issue
13eissn
0014-5793issn
1873-3468pii
S0014-5793(12)00389-4journal_volume
586pub_type
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