Abstract:
:Endothelial dysfunction plays a major role in the pathogenesis of atherosclerosis. Pro-inflammatory cytokines such as interleukin-1 beta and tumour necrosis factor alpha activate endothelial cells changing their resting phenotype to become pro-adhesive, pro-thrombotic and pro-atherogenic. Phage display in vivo biopanning has been used to identify peptide sequences that home to diseased regions of the vessel wall in low density lipoprotein receptor (LDLr) knockout mice. In LDLr knockout mice, peptide sequence determinants exhibiting organ specificity have been isolated. These sequences have applications for gene delivery, drug delivery and for improving contrast agents for vascular imaging.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Houston P,Goodman J,Lewis A,Campbell CJ,Braddock Mdoi
10.1016/s0014-5793(01)02191-3keywords:
subject
Has Abstractpub_date
2001-03-09 00:00:00pages
73-7issue
1-2eissn
0014-5793issn
1873-3468pii
S0014-5793(01)02191-3journal_volume
492pub_type
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