Abstract:
:The cytochrome bc1 complex is a key component of the mitochondrial respiratory chains of many eukaryotic microorganisms that are pathogenic for plants or humans, such as fungi responsible for crop diseases and Plasmodium falciparum, which causes human malaria. Cytochrome bc1 is an enzyme that contains two (ubi)quinone/quinol-binding sites, which can be exploited for the development of fungicidal and chemotherapeutic agents. Here, we review recent progress in determination of the structure and mechanism of action of cytochrome bc1 , and the associated development of antimicrobial agents (and associated resistance mechanisms) targeting its activity.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Fisher N,Meunier B,Biagini GAdoi
10.1002/1873-3468.13868subject
Has Abstractpub_date
2020-09-01 00:00:00pages
2935-2952issue
18eissn
0014-5793issn
1873-3468journal_volume
594pub_type
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