The cytochrome bc1 complex as an antipathogenic target.

Abstract:

:The cytochrome bc1 complex is a key component of the mitochondrial respiratory chains of many eukaryotic microorganisms that are pathogenic for plants or humans, such as fungi responsible for crop diseases and Plasmodium falciparum, which causes human malaria. Cytochrome bc1 is an enzyme that contains two (ubi)quinone/quinol-binding sites, which can be exploited for the development of fungicidal and chemotherapeutic agents. Here, we review recent progress in determination of the structure and mechanism of action of cytochrome bc1 , and the associated development of antimicrobial agents (and associated resistance mechanisms) targeting its activity.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Fisher N,Meunier B,Biagini GA

doi

10.1002/1873-3468.13868

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

2935-2952

issue

18

eissn

0014-5793

issn

1873-3468

journal_volume

594

pub_type

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