Abstract:
:Y RNAs are approximately 100 nucleotide long conserved cytoplasmic non-coding RNAs, which produce smaller RNA fragments during apoptosis. Here we show that these smaller RNA molecules are also produced in non-stressed cells and in a range of human cancerous and non-cancerous cell types. Recent reports have speculated that the cleavage products of Y RNAs enter the microRNA pathway. We tested this hypothesis and found that Y5 and Y3 RNA fragments are Dicer independent, they are in different complexes than microRNAs and that they are not co-immunoprecipitated with Ago2. Therefore we conclude that Y RNA fragments do not enter the microRNA pathway.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Nicolas FE,Hall AE,Csorba T,Turnbull C,Dalmay Tdoi
10.1016/j.febslet.2012.03.026subject
Has Abstractpub_date
2012-04-24 00:00:00pages
1226-30issue
8eissn
0014-5793issn
1873-3468pii
S0014-5793(12)00226-8journal_volume
586pub_type
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