Abstract:
:We report here the regulation of the biosynthesis and the secretion of C-type natriuretic peptide (CNP) in cultured bovine chromaffin cells. The combined treatment with protein kinase A and -C activators induced a 6-fold increase of intracellular levels of CNP-(1-103). The biosynthesized CNP-(1-103) was co-released with its mature forms, typically CNP-(51-103), upon stimulation by nicotine or depolarizing agents. This confirms the neuropeptidic character of this third member of the natriuretic peptide family, which might act as a neuromodulator or neurotransmitter.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Babinski K,Féthière J,Roy M,De Léan A,Ong Hdoi
10.1016/0014-5793(92)81214-7keywords:
subject
Has Abstractpub_date
1992-11-30 00:00:00pages
300-2issue
3eissn
0014-5793issn
1873-3468pii
0014-5793(92)81214-7journal_volume
313pub_type
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